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Substitution at R3 with a halogen or alkoxy group (74f–74i) resulted in a slight increase in cellular potency Using the halide analogs (74g–h) showing highest the potency in the group. Further optimization resulted in the invention of 74i–j, with 74k as the most Lively compound while in the series (pIC50 = six.77) with very good LLE values.Ba
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